PIVOTAL: Prioritizing variants of uncertain significance with spatial genomic patterns in 3D proteome
PIVOTAL is a computational tool for prioritizing variants of uncertain significance (VUS), utilizing the spatial distribution of known disease mutations, evolutionary conservation and co-evolution on three-dimensional protein structures. To get started, search for your variants, protein or disease of interest.

Search by variant

Input residue-level mutations with UniProt residue numbers or nucleotide-level mutations with chromosome coordinates.
Either paste data:
Or upload file:
Example data Example file (GRCh37)

Search by protein or gene

Input UniProt accession or gene name.
Example 1 Example 2

Search by disease

Input disease name or MedGen Concept ID.
Example 1 Example 2